Climate change and vulnerability impacts are magnifying from day to day. Our ecosystems are degrading at alarming rate threatening biodiversity including human lives. Species on earth are trying to adapt and mitigate impacts of the changing climate. In a process, poor communities are extremely hit and while facing limited capacity to become more resilient on the changing climate. Tanzania Alliance for Climate and Sustainable Society (TACSS) in collaboration with local and international stakeholders works to support building adaptive capacity of poor communities while promoting mitigation measures for low carbon development. TACSS join hand this initiative through networking and partnerships, capacity enhancement, conducting research, evidence-based advocacy, good governance, fostering low emission and sustainable development pathways, and practices. From this base, I therefore call for multidimensional approaches that intend to utilize informed interventions for better policies and practices for human well-being and fostering sustainable development.